ARTICLES


Stanton JE, Malijauskaite S, McGourty K, Grabrucker AM. The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders. Front Mol Neurosci 2021; 14: 695873. 


Hill-Yardin EL, Grabrucker AM, Franks AE, Luna RA, Monif M. Editorial: Interactions of the Nervous System With Bacteria. Front Neurosci 2021; 15: 682744. 


De Benedictis CA, Haffke C, Hagmeyer S, Sauer AK, Grabrucker AM. Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4. Int J Mol Sci 2021; 22 (9).


Romero-Aguirregomezcorta J, Laguna-Barraza R, Fernández-González R, Štiavnická M, Ward F, Cloherty J, McAuliffe D, Larsen PB, Grabrucker AM, Gutiérrez-Adán A, Newport D, Fair S. Sperm selection by rheotaxis improves sperm quality and early embryo development. Reproduction 2021; 161 (3): 343-352.


Grabrucker S, Pagano J, Schweizer J, Urrutia-Ruiz C, Schön M, Thome K, Ehret G, Grabrucker AM, Zhang R, Hengerer B, Bockmann J, Verpelli C, Sala C, Boeckers TM. Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism. EMBO J 2021; 40 (5): e104267.


Sarowar T, Grabrucker AM. Rho GTPases in the Amygdala-A Switch for Fears? Cells 2020; 9 (9).


Sauer AK, Vela H, Vela G, Stark P, Barrera-Juarez E, Grabrucker AM. Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders. Front Oncol 2020; 10: 1293.


DeBenedictis CA, Raab A, Ducie E, Howley S, Feldmann J, Grabrucker AM. Concentrations of Essential Trace Metals in the Brain of Animal Species-A Comparative Study. Brain Sci 2020; 10 (7).


Lutz AK, Pfaender S, Incearap B, Ioannidis V, Ottonelli I, Fhr KJ, Cammerer J, Zoller M, Higelin J, Giona F, Stetter M, Stoecker N, Alami NO, Schn M, Orth M, Liebau S, Barbi G, Grabrucker AM, Delorme R, Mayer B, Jesse S, Roselli F, Ludolph AC, Bourgeron T, Verpelli C, Demestre M, Boeckers TM. Autism-associated SHANK3 mutations impair maturation of neuro-muscular junctions and striated muscles. Science Transl. Med. 2020 (Epub ahead of print).


Ross AM, Kennedy T, Mc Nulty D, Walsh D, Grabrucker AM, Mulvihill JJE. Comparing nanoparticles for drug delivery: the effect of physiological dispersion media on nanoparticle properties. Materials Science & Engineering C. 2020; (Epub ahead of print).


Oddone N, Boury F, Garcion E, Grabrucker AM, Del Carmen Martinez M, Da F, Janaszewska A, Forni F, Vandelli MA, Tosi G, Ruozi B, Duskey JT. Synthesis, characterization, and in vitro studies of a ROS- responsive mPEG-TK-MPH prodrug for Glioblastoma. Front. In Pharmacology. 2020 (Epub ahead of print).


Mulvihill JJ, Cunnane EM, Ross AM, Duskey JT, Tosi G, Grabrucker AM. Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers. Nanomedicine (Lond) 2020; 15 (2): 205-214.


Sauer AK, Grabrucker AM. Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice. Front Neurosci 2019; 13: 1295.


Pederzoli F, Ruozi B, Duskey J, Hagmeyer S, Sauer AK, Grabrucker S, Coelho R, Oddone N, Ottonelli I, Daini E, Zoli M, Vandelli MA, Tosi G, Grabrucker AM. Nanomedicine Against Aβ Aggregation by β-Sheet Breaker Peptide Delivery: In Vitro Evidence. Pharmaceutics 2019; 11 (11)


Oddone N, Pederzoli F, Duskey JT, De Benedictis CA, Grabrucker AM, Forni F, Angela Vandelli M, Ruozi B, Tosi G. ROS-responsive "smart" polymeric conjugate: Synthesis, characterization and proof-of-concept study. Int J Pharm 2019; 570: 118655.


Hagmeyer S, Romão MA, Cristóvão JS, Vilella A, Zoli M, Gomes CM, Grabrucker AM. Distribution and Relative Abundance of S100 Proteins in the Brain of the APP23 Alzheimer's Disease Model Mice. Front Neurosci 2019; 13: 640.


Sauer AK, Bockmann J, Steinestel K, Boeckers TM, Grabrucker AM. Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model. Int J Mol Sci 2019; 20 (9).


Schoen M, Asoglu H, Bauer HF, Müller HP, Abaei A, Sauer AK, Zhang R, Song TJ, Bockmann J, Kassubek J, Rasche V, Grabrucker AM, Boeckers TM. Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI. Front Neural Circuits 2019; 13


Ross AM, Mc Nulty D, O'Dwyer C, Grabrucker AM, Cronin P, Mulvihill JJE. Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives. J Control Release 2019; 296: 202-224.


Hagmeyer S, Sauer AK, Grabrucker AM. Prospects of Zinc Supplementation in Autism Spectrum Disorders and Shankopathies Such as Phelan McDermid Syndrome. Front Synaptic Neurosci 2018; 10): 11.


Belletti D, Grabrucker AM, Pederzoli F, Menerath I, Vandelli MA, Tosi G, Duskey TJ, Forni F, Ruozi B. Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain. Int J Pharm 2018; 543 (1-2): 300-310


Hagmeyer S, Cristóvão JS, Mulvihill JJ, Boeckers TM, Gomes CM, Grabrucker AM. Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain. Front. Mol. Neurosci. 2017; 10:456.


Grabrucker S, Haderspeck JC, Sauer AK, Kittelberger N, Asoglu H, Abaei A, Rasche V, Schoen M, Boeckers TM, Grabrucker AM. Brain lateralization in mice is associated with zinc signaling and
altered in prenatal zinc deficient mice that display features of  autism spectrum disorder. Front. Mol. Neurosci. 2017 10:450.


Vilella A, Belletti B, Sauer AK, Hagmeyer S, Sarowar T, Masoni M, Stasiak N, Mulvihill JJE, Ruozi B, Forni F, Vandelli MA, Tosi G, Zoli M, Grabrucker AM. Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer’s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery. J Trace Elem Med Biol 2018; 49: 210-221.


Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am J Hum Genet 2017; 101 (5): 768-788. 


Sauer AK, Pfaender S, Hagmeyer S, Tarana L, Mattes AK, Briel F, Küry S, Boeckers TM, Grabrucker AM. Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC. Biometals, 2017; 30 (5): 643-661.


Sarowar T, Grabrucker S, Boeckers TM, Grabrucker AM. Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2, Front. Mol. Neurosci. 2017; 10: 180.


Ruozi B, Belletti D, Pederzoli F, Masoni M, Keller J, Ballestrazzi A, Vandelli MA, Tosi G, Grabrucker AM. Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates. Int. Journal of Pharmaceutics 2017; 526 (1-2): 413-424


Ardiles AO, Grabrucker AM, Scholl FG, Rudenko G, Borsello T. Molecular and Cellular Mechanisms of Synaptopathies. Neural Plasticity 2017; 2017: 2643943. (Editorial)


Pfaender S, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau S, Bockmann J, Huguet G, Bourgeron T, Boeckers TM, Grabrucker AM. Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3, SciRep, 2017; 7: 45190.


Sarowar T, Grabrucker AM: Actin-dependent alterations of dendritic spine morphology in
Shankopathies. Neural Plasticity 2016; 2016: 8051861.


Belletti D, Grabrucker AM, Pederzoli F, Menrath I, Capello V, Vandelli MA, Forni F, Tosi G, Ruozi B: Exploiting the versatility of Cholesterol Nanoparticles formulation. Int. Journal of Pharmaceutics. 2016; 511 (1): 331-340.


Sarowar T, Chhabra R, Vilella A, Boeckers TM, Zoli M, Grabrucker AM: Activity and circadian rhythm influence synaptic Shank3 protein levels in mice. J. Neurochem. 2016, 138 (6): 887-95. 


Reim D, Weis T, Halbedl S, Grabrucker AM, Schmeisser MJ, Boeckers TM: The Shank3 interaction partner ProSAPiP1 regulates postsynaptic SPAR levels and the maturation of dendritic spines in hippocampal neurons. Front Synaptic Neurosci 2016; 8:13.


Pfaender S, Föhr K, Lutz AK, Putz S, Achberger K, Linta L, Liebau S, Boeckers TM, Grabrucker AM: Cellular zinc homeostasis contributes to neuronal differentiation in human induced pluripotent stem cells. Neural Plasticity 2016; 2016: 3760702.


Grabrucker S, Boeckers TM, Grabrucker AM: Gender dependent evaluation of autism like behavior in mice exposed to prenatal zinc deficiency. Front Behav Neurosci 2016; 10: 37.


Sarowar T, Grabrucker S, Föhr T, Mangus K, Eckert M, Bockmann J, Boeckers TM, Grabrucker AM: Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Mol. Brain, 2016; 9 (1): 28.


Grabrucker AM, Ruozi B, Belletti D, Pederzoli F, Forni F, Vandelli MA, Tosi G: Nanoparticle transport across the BBB. Tissue Barriers, 2016; 4 (1): e1153568.


Chhabra R, Ruozi B, Vilella A, Belletti D, Mangus K, Pfaender S, Sarowar T, Boeckers TM, Zoli M, Forni F, Vandelli MA, Tosi G, Grabrucker AM: Application of polymeric nanoparticles for CNS targeted zinc delivery in vivo. CNS & Neurological Disorders-Drug Targets 2015; 14 (8): 1041-53.


Chhabra R, Tosi G, Grabrucker AM: Emerging use of nanotechnology in the treatment of neurological disorders. Current Pharmaceutical Design 2015; 21 (22): 3111-30.


Vela G, Stark P, Socha M, Sauer AK, Hagmeyer S, Grabrucker AM: Zinc in gut – brain interaction in Autism and neurological disorders. Neural Plasticity 2015; 2015: 972791


Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM: Effects of trace metal profiles characteristic for autism on synapses in cultured neurons. Neural Plasticity 2015; 2015: 985083


Heiliger, E, Osmanagic A, Haase H, Golenhofen N, Grabrucker AM, Weth A, Baumgartner W: N-cadherin-mediated cell adhesion is regulated by extracellular Zn2+. Metallomics 2015; 7 (2): 355-62


Hagmeyer S, Haderspeck J, Grabrucker AM: Behavioral impairments in animal models for zinc deficiency. Front. Behav. Neurosci. 2015; 8:443


Baecker T, Mangus K, Pfaender S, Chhabra R, Boeckers TM, Grabrucker AM: Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals 2014; 27 (4): 715-30.


Chhabra R, Grabrucker AM, Veratti P, Belletti D, Boeckers TM, Vandelli MA, Forni F, Tosi G, Ruozi B: Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. International Journal of Pharmaceutics 2014; 471 (1-2): 349-357.


Pfaender S, Grabrucker AM: Characterization of biometal - profiles in neurological disorders. Metallomics, 2014; 6 (5): 960-77.


Vilella A, Tosi G, Grabrucker AM, Ruozi B, Belletti D, Vandelli MA, BoeckerS TM, Forni F, Zoli M: Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution. Journal of Controlled Release 2014; 174: 195-201.


Tosi G, Vilella A, Schmeisser MJ, BoeckerS TM, Ruozi B, Vandelli MA, Forni F, Zoli M, Grabrucker AM: Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport Journal of Controlled Release 2014; 177C: 96-107.


Grabrucker S, Jannetti L, Eckert M, Gaub S, Chhabra R, Pfaender S, Mangus K, Reddy PP, Rankovic V, Schmeisser MJ, Kreutz MR, Ehret G, Boeckers TM, Grabrucker AM: Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain 2014; 137 (Pt 1): 137-52.


Grabrucker AM. A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders. Dev. Neurobiology. 2014; 74 (2): 136-46.


Grabrucker S, Proepper C, Mangus K, Eckert M, Chhabra R, Schmeisser MJ, Boeckers TM, Grabrucker AM. The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation. Exp Neurol 2014; 253: 126-37.


Schmeisser MJ, Kühl S, Beth N, Weis TM, Schoen M, Grabrucker AM, Kühl M, Boeckers TM. The Nedd4 binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Development 2013, 8 (1): 18.


Grabrucker AM, Environmental factors in autism. Front. Psychiatry. 2012, 3: 118.


Arons M, Thynne CJ, Grabrucker AM, Li D, Schoen M, Cheyne JE, Boeckers TM, Montgomery JM, Garner CC. Autism associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin mediated transsynaptic signaling. J. Neurosci. 2012, 32 (43): 14966-78.


Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM: Abnormal glutamate neurotransmission, hyperactivity and autistic-like behaviours in mice lacking ProSAP1/Shank2. Nature, 2012, 486(7402):256-60


Grabrucker AM, Schmeisser MJ, Udvardi PT, Rowan M, Schoen M, Woodling NS, Andreasson KI, Hof PR, Buxbaum JD, Garner CC, Boeckers TM: Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Mol. Neurodeg. 2011, 6: 65.


Grabrucker AM, Schmeisser MJ, Schoen M, Boeckers TM: Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Trends in Cell Biology 2011, (10): 594-603.


Grabrucker AM, Rowan M, Garner CC: Brain-delivery of Zinc-ions as potential treatment for neurological diseases. Drug Delivery Letters 2011, 1 (1) 13-23.


Grabrucker AM, Garner CC, Boeckers TM, Bondioli L, Ruozi B, Forni F, Vandelli MA, Tosi G: Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Plos One 2011, 6 (3): e17851.


Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM: Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO Journal 2011, 30 (3): 569-581.


Vellanki SH, Grabrucker A, Liebau S, Proepper C, Eramo A, Braun V, Boeckers T, Debatin KM, Fulda S: Small molecule XIAP inhibitors enhance gamma- irradiation-induced apoptosis in preclinical models of glioblastoma. Neoplasia. 2009, 11(8): 743-752.


Grabrucker AM, Vaida B, Bockmann J, Boeckers TM: Synaptogenesis of hippocampal neurons in primary cell culture, Cell and Tissue Research. 2009, 338: 333–341.


Schmeisser MJ, Grabrucker AM, Bockmann J, Boeckers TM: Synaptic crosstalk between NMDA receptors and LAPSER1/ß-catenin at excitatory synapses. J Biol Chem. 2009, 284(42): 29146-29157.


Grabrucker AM Vaida B, Bockmann J, Boeckers TM: Efficient targeting of proteins to postsynaptic densities of excitatory synapses using a novel pSDTarget vector system. Journal of Neuroscience Methods. 2009, 181(2): 227-234.



BOOK CHPATERS


Sauer AK, Dooley L, Vaughan A, Grabrucker AM, Chapter 7 - Altered gut–brain signaling in autism spectrum disorders—from biomarkers to possible intervention strategies, Editor(s): Ayman S. El-Baz, Jasjit S. Suri, Neural Engineering Techniques for Autism Spectrum Disorder, Academic Press, 2021, pp. 127-149.


Ross AM, Grabrucker AM, McGourty KM, Mulvihill JJE. Metallic-based nanocarriers: Methods employed in nanoparticle characterization and assessing the interaction with the blood-brain barrier. In: Sigh RW, Singh D, Kanwar J, Singh Chauha N (Eds): Advances and Avenues in the Development of Novel Carriers for Bioactives. ELSEVIER, 2020


Vilella A, Daini E, De Benedictis CA, Grabrucker AM. Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer’s Disease. In: Huang X, editor. Alzheimer’s Disease: Drug Discovery [Internet]. Brisbane (AU): Exon Publications; 2020 Dec 18. Chapter 5.


De Benedictis CA, Vilella A, Grabrucker AM. Chapter 6: The role of trace metals in Alzheimer’s Disease. In Alzheimer’s Disease, Thomas Wisniewski (Editor), Exon Publications, Brisbane, Australia. 2019, pp. 87-108.


Cristóvão JS, Moreira GG, Grabrucker AM, Gomes CM. Chapter 9: Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases, in Protein Homeostasis Diseases, ELSEVIER, 2019


Hill-Yardin EL, McKeown SJ, Novarino G, Grabrucker AM. Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder. Adv Anat Embryol Cell Biol 2017; 224: 159-187.


Grabrucker S, Grabrucker AM: Chapter 9: Zinc and autism, in White A (Ed): Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. Elsevier, 2017 


Sauer AK, Hagmeyer S, Grabrucker AM: Zinc Deficiency, in: Pinar Erekolu (Ed): Nutritional Deficiency, InTech open science, 2016, pp.23-46.


Sarowar T, Grabrucker AM. Nanomedicine and Neurodegenerative Diseases: An Introduction to Pathology and Drug Targets, in: Tosi G (Ed): Frontiers in Nanomedicine: Nanomedicine and Neuroscience. Bentham Science Publishers, 2017 


Tosi G, Ruozi B, Vilella A, Grabrucker AM, Belletti D, Vandelli MA, Boeckers TM, Forni F, Zoli M, Sharma A, Muresanu DF, Sharma HS. Nanomedicine in neurodegenerative disorders: Understanding the journey. NSTI: Advanced Materials - TechConnect Briefs 2015, 3 pp. 25 - 28.


Grabrucker AM. Zinc in the developing brain, in: Moran VH, Lowe N (Eds): Nutrition and the developing brain. CRC Press, 2016, pp.143-168.


Grabrucker AM, Schmeisser MJ: Ursachen, in: G. Theunissen (Ed): Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht, 2014; Stuttgart: Kohlhammer, pp. 382-392. 


Grabrucker AM, Chhabra R, Belletti D, Forni F, Vandelli MA, Ruozi B, Tosi G. Nanoparticles as Blood-Brain Barrier Permeable CNS Targeted Drug Delivery Systems. Top Med Chem. 2014, 10: 71-90 



BOOKS


GRABRUCKER AM. Biometals in Autism Spectrum disorders. Academic Press, 2020


GRABRUCKER AM. Eco-Neurobiology, and how the environment shapes our brain. Cambridge Scholars, 2019