Department of Biological Sciences
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![Articles
Hagmeyer s, Sauer AK, Grabrucker AM. Prospects of zinc supplementation in Autism Spectrum Disorders and Shankopathies such as Phelan McDermid Syndrome. Front. Synaptic Neurosci. 2018; 10:11.
Belletti D, Grabrucker AM, Pederzoli F, Menerath I, Vandelli MA, Tosi G, Duskey TJ, Forni F, Ruozi B. Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain. Int J Pharm 2018; 543 (1-2): 300-310
Hagmeyer S, Cristóvão JS, Mulvihill JJE, Boeckers TM, Gomes CM, Grabrucker AM. Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain. Front. Mol. Neurosci. 2017; 10: 456.
Grabrucker S, Haderspeck JC, Sauer AK, Kittelberger N, Asoglu H, Abaei A, Rasche V, Schoen M, Boeckers TM, Grabrucker AM. Brain lateralization in mice is associated with zinc signaling and altered in prenatal zinc deficient mice that display features of autism spectrum disorder. Front. Mol. Neurosci. 2017; 10: 450.
Vilella A, Belletti B, Sauer AK, Hagmeyer S, Sarowar T, Masoni M, Stasiak N, Mulvihill JJE, Ruozi B, Forni F, Vandelli MA, Tosi G, Zoli M, Grabrucker AM. Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer’s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery. J Trace Elem Med Biol, 2017; [in press]
Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am J Hum Genet 2017; 101 (5): 768-788.
SAUER AK, PFAENDER S, HAGMEYER S, TARANA L, MATTES AK, BRIEL F, KURY S, BOECKERS TM, GRABRUCKER AM. Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC. Biometals, 2017;
SAROWAR T, GRABRUCKER S, BOECKERS TM, GRABRUCKER AM. Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2, Front. Mol. Neurosci. 2017; 10: 180.
RUOZI B, BELLETTI D, PEDERZOLI F, MASONI M, KELLER J, BALLESTRAZZI A, VANDELLI MA, TOSI G, GRABRUCKER AM. Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates. Int J Pharm 2017; 526 (1-2): 413-424
ARDILES AO, GRABRUCKER AM, SCHOLL FG, RUDENKO G, BORSELLO T. Molecular and Cellular Mechanisms of Synaptopathies. Neural Plasticity 2017; 2017: 2643943. (Editorial)
Pfaender S, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau S, Bockmann J, Huguet G, Bourgeron T, Boeckers TM, Grabrucker AM. Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3, SciRep, 2017; 7:45190.
SAROWAR T, GRABRUCKER AM: Actin-dependent alterations of dendritic spine morphology in Shankopathies. Neural Plasticity 2016; 2016: 80511861
BELLETTI D, GRABRUCKER AM, PEDERZOLI F, MENRATH I, CAPELLO V, VANDELLIi MA, FORNI F, TOSI G, RUOZI B: Exploiting the versatility of Cholesterol Nanoparticles formulation. Int J Pharm 2016; 511 (1): 331-340.
SAROWAR T, CHHABRA R, VILELLA A, BOECKERS TM, ZOLI M, GRABRUCKER AM: Activity and circadian rhythm influence synaptic Shank3 protein levels in mice. J. Neurochem. 2016; 138 (6): 887-95.
REIM D, WEIS T, HALBEDL S, GRABRUCKER AM, SCHMEISSER MJ, BOECKERS TM: The Shank3 interaction partner ProSAPiP1 regulates postsynaptic SPAR levels and the maturation of dendritic spines in hippocampal neurons. Front Synaptic Neurosci 2016; 8:13.
PFAENDER S, FÖHR K, LUTZ AK, PUTZ S, ACHBERGER K, LINTA L, LIEBAU S, BOECKERS TM, GRABRUCKER AM: Cellular zinc homeostasis contributes to neuronal differentiation in human induced pluripotent stem cells. Neural Plasticity 2016; 2016: 3760702.
SAROWAR T, GRABRUCKER S, FÖHR K, MANGUS K, ECKERT M, BOCKMANN J, BOECKERS TM, GRABRUCKER AM: Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Mol. Brain, 2016; 9 (1): 28.
GRABRUCKER S, BOECKERS TM, GRABRUCKER AM: Gender dependent evaluation of autism like behavior in mice exposed to prenatal zinc deficiency. Front. Behav. Neurosci. 2016 ;10: 37.
GRABRUCKER AM, RUOZI B, BELLETTI D, PEDERZOLI F, FORNI F, VANDELLI MA, TOSI G: Nanoparticle transport across the BBB. Tissue Barriers, 2016; 4 (1): e1153568.
Chhabra R, Ruozi B, Vilella A, Belletti D, Mangus K, Pfaender S, Sarowar T, Boeckers TM, Zoli M, Forni F, Vandelli MA, Tosi G, Grabrucker AM: Application of polymeric nanoparticles for CNS targeted zinc delivery in vivo. CNS & Neurological Disorders-Drug Targets 2015; 14 (8): 1041-53.
Chhabra R, Tosi G, Grabrucker AM: Emerging use of nanotechnology in the treatment of neurological disorders. Current Pharmaceutical Design 2015; 21 (22): 3111-30.
Vela G, Stark P, Socha M, Sauer AK, Hagmeyer S, Grabrucker AM: Zinc in gut – brain interaction in Autism and neurological disorders. Neural Plasticity 2015; 2015: 972791
Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM: Effects of trace metal profiles characteristic for autism on synapses in cultured neurons. Neural Plasticity 2015; 2015: 985083
Heiliger, E, Osmanagic A, Haase H, Golenhofen N, Grabrucker AM, Weth A, Baumgartner W: N-cadherin-mediated cell adhesion is regulated by extracellular Zn2+. Metallomics 2015; 7 (2): 355-62.
Hagmeyer S, Haderspeck J, Grabrucker AM: Behavioral impairments in animal models for zinc deficiency. Front. Behav. Neurosci. 2015; 8: 443.
Baecker T, Mangus K, Pfaender S, Chhabra R, Boeckers TM, Grabrucker AM: Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals 2014; 27 (4): 715-30.
Chhabra R, Grabrucker AM, Veratti P, Belletti D, Boeckers TM, Vandelli MA, Forni F, Tosi G, Ruozi B: Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. Int J Pharm 2014; 471 (1-2): 349-357.
Pfaender S, Grabrucker AM: Characterization of biometal - profiles in neurological disorders. Metallomics, 2014; 6 (5): 960-77
Vilella A, Tosi G, Grabrucker AM, Ruozi B, Belletti D, Vandelli MA, BoeckerS TM, Forni F, Zoli M: Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution. Journal of Controlled Release 2014; 174: 195-201.
Tosi G, Vilella A, Schmeisser MJ, BoeckerS TM, Ruozi B, Vandelli MA, Forni F, Zoli M, Grabrucker AM: Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport Journal of Controlled Release 2014; 177C: 96-107.
Grabrucker S, Jannetti L, Eckert M, Gaub S, Chhabra R, Pfaender S, Mangus K, Reddy PP, Rankovic V, Schmeisser MJ, Kreutz MR, Ehret G, Boeckers TM, Grabrucker AM: Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain 2014; 137 (Pt 1): 137-52.
GRABRUCKER AM. A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders. Dev. Neurobiology. 2014; 74 (2): 136-46.
Grabrucker S, Proepper C, Mangus K, Eckert M, Chhabra R, Schmeisser MJ, Boeckers TM, Grabrucker AM. The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation. Exp Neurol 2014; 253: 126-37.
Schmeisser MJ, Kühl S, Beth N, Weis TM, Schoen M, Grabrucker AM, Kühl M, Boeckers TM. The Nedd4 binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Development 2013, 8 (1): 18.
Grabrucker AM, Environmental factors in autism. Front. Psychiatry. 2012, 3: 118.
Arons M, Thynne CJ, Grabrucker AM, Li D, Schoen M, Cheyne JE, Boeckers TM, Montgomery JM, Garner CC. Autism associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin mediated transsynaptic signaling. J. Neurosci. 2012, 32 (43): 14966-78.
Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM: Abnormal glutamate neurotransmission, hyperactivity and autistic-like behaviours in mice lacking ProSAP1/Shank2. Nature, 2012, 486(7402):256-60
GRABRUCKER AM, SCHMEISSER MJ, UDVARDI PT, ROWAN M, SCHOEN M, WOODLING NS, ANDREASSON KI, HOF PR, BUXBAUM JD, GARNER CC, BOECKERS TM: Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Mol. Neurodeg. 2011, 6: 65.
GRABRUCKER AM, SCHMEISSER MJ, SCHOEN M, BOECKERS TM: Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Trends in Cell Biology 2011, (10): 594-603.
GRABRUCKER AM, ROWAN M, GARNER CC: Brain-delivery of Zinc-ions as potential treatment for neurological diseases. Drug Delivery Letters 2011, 1 (1) 13-23.
Grabrucker AM, Garner CC, Boeckers TM, Bondioli L, Ruozi B, Forni F, Vandelli MA, Tosi G: Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Plos One 2011, 6 (3): e17851.
Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM: Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO Journal 2011, 30 (3): 569-581.
VELLANKI SH, GRABRUCKER A, LIEBAU S, PROEPPER C, ERAMO A, BRAUN V, BOECKERS T, DEBATIN KM, FULDA S: Small molecule XIAP inhibitors enhance gamma- irradiation-induced apoptosis in preclinical models of glioblastoma. Neoplasia. 2009, 11(8): 743-752.
GRABRUCKER AM, VAIDA B, BOCKMANN J, BOECKERS TM: Synaptogenesis of hippocampal neurons in primary cell culture, Cell and Tissue Research. 2009, 338: 333–341.
SCHMEISSER MJ, GRABRUCKER AM, BOCKMANN J, BOECKERS TM: Synaptic crosstalk between NMDA receptors and LAPSER1/ß-catenin at excitatory synapses. J Biol Chem. 2009, 284(42): 29146-29157.
GRABRUCKER AM, VAIDA B, BOCKMANN J, BOECKERS TM: Efficient targeting of proteins to postsynaptic densities of excitatory synapses using a novel pSDTarget vector system. Journal of Neuroscience Methods. 2009, 181(2): 227-234.
BOOK CHAPTERS
HILL-YARDIN EL, McKEOWN SJ, NOVARINO G, GRABRUCKER AM: Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder. Adv Anat Embryol Cell Biol 2017, 224: 159-187.
GRABRUCKER S, GRABRUCKER AM: Chapter 9: Zinc and autism, in White A (Ed): Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. Elsevier, 2017, pp. 153-173.
SAUER AK, HAGMEYER S, GRABRUCKER AM: Zinc Deficiency, in: Pinar Erekolu (Ed): Nutritional Deficiency, InTech open science, 2016, pp.23-46.
SAROWAR T, GRABRUCKER AM. Nanomedicine and Neurodegenerative Diseases: An Introduction to Pathology and Drug Targets, in: Tosi G (Ed): Frontiers in Nanomedicine: Nanomedicine and Neuroscience. Bentham Science Publishers, 2017, pp. 3-74.
GRABRUCKER AM. Zinc in the developing brain, in: Moran VH, Lowe N (Eds): Nutrition and the developing brain. CRC Press, 2016, pp.143-168.
Tosi G, Ruozi B, Vilella A, Grabrucker AM, Belletti D, Vandelli MA, Boeckers TM, Forni F, Zoli M, Sharma A, Muresanu DF, Sharma HS. Nanomedicine in neurodegenerative disorders: Understanding the journey. NSTI: Advanced Materials - TechConnect Briefs 2015, 3 pp. 25 - 28.
GRABRUCKER AM, SCHMEISSER MJ: Ursachen, in: G. Theunissen (Ed): Handlexikon Autismus-Spektrum: Schlüsselbegriffe aus Forschung, Theorie, Praxis und Betroffenen-Sicht, 2014; Stuttgart: Kohlhammer, pp. 382-392.
GRABRUCKER AM, CHHABRA R, BELLETTI D, FORNI F, VANDELLI MA, RUOZI B, TOSI G. Nanoparticles as Blood-Brain Barrier Permeable CNS Targeted Drug Delivery Systems. Top Med Chem. 2014, 10: 71-90](Publications_Grabrucker_files/shapeimage_3.png)
