Department of Biological Sciences

 

Research Summary - Treatment/Evaluation


Our group’s research interests are focused on the translation of novel treatment and prevention strategies focusing on Alzheimer”s disease and Autism.


The key areas of interest where we have developed expertise are:

  1. Nanotechnology


  1. Nutraceuticals


To understand saftey, kinetics and effects, we have developed assessment models for the investigation of novel nanoparticles and nutraceuticals in biologically relevant cull culture and animal models.


Current projects:

Characterization of Zinc amino acids conjugates (ZnAAs)








RESEARCH experience:


Articles


Vela G, Stark P, Socha M, Sauer AK, Hagmeyer S, Grabrucker AM: Zinc in gut – brain interaction in Autism and neurological disorders. Neural Plasticity 2015; 2015: 972791


Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM: Effects of trace metal profiles characteristic for autism on synapses in cultured neurons. Neural Plasticity 2015; 2015: 985083


Hagmeyer S, Haderspeck J, Grabrucker AM: Behavioral impairments in animal models for zinc deficiency. Front. Behav. Neurosci. 2015; 8: 443. 


GRABRUCKER AM. A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders. Dev. Neurobiology. 2014; 74 (2): 136-46.


GRABRUCKER AM, ROWAN M, GARNER CC: Brain-delivery of Zinc-ions as potential treatment for neurological diseases. Drug Delivery Letters 2011, 1 (1) 13-23.


BOOK CHAPTERS


SAUER AK, HAGMEYER S, GRABRUCKER AM: Zinc Deficiency, in: Pinar Erekolu (Ed): Nutritional Deficiency, InTech open science, 2016, pp.23-46.


GRABRUCKER AM. Zinc in the developing brain, in: Moran VH, Lowe N (Eds): Nutrition and the developing brain. CRC Press, 2016, pp.143-168.